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Tylenol Arthritis Pain 8HR Pain Reliever 650mg 225 Caplets Tylenol 8 Hour Arthritis Pain Extended Release Caplets temporarily relieves the minor pain of arthritis. The bi-layer design delivers fast-acting, effective pain relief that lasts up to 8 hours. With 650 milligrams of acetaminophen per caplet, this pain medicine also temporarily relieves aches and pains associated with muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, and toothache. This effective oral pain reliever is gentle on your stomach, but tough on body pain and also works as a fever reducer.